Hepatocellular Ballooning is Due to Highly Pronounced Glycogenosis Potentially Associated with Steatosis and Metabolic Reprogramming.

Silvia RibbackKristin PetersMohd YasserJessica PreyPaula WilhelmiQin SuFrank DombrowskiPeter Bannasch

Published in: Journal of clinical and translational hepatology (2023)

BH are hallmarked by particularly pronounced glycogenosis with facultative steatosis, many of their features being reminiscent of metabolic aberrations documented in preneoplastic hepatocellular lesions in experimental animals and chronic human liver diseases. Hence, BH are not damaged entities facing death but rather viable cells featuring metabolic reprogramming, indicative of a preneoplastic nature.

Keyphrases

insulin resistance
high fat diet
induced apoptosis
cell cycle arrest
metabolic syndrome
dna methylation
copy number
skeletal muscle
pi k akt