Local cryotherapy improves adjuvant-induced arthritis through down-regulation of IL-6 / IL-17 pathway but independently of TNFα.
Xavier GuillotHélène MartinStéphanie Seguin-PyKaty Maguin-GatéJohnny MorettoPerle TotosonDaniel WendlingCéline DemougeotNicolas TordiPublished in: PloS one (2017)
We demonstrated for the first time that sub-chronically applied local cryotherapy (ice and cold gas) is an effective and well-tolerated treatment in adjuvant-induced arthritis. Furthermore, we provided novel insights into the cytokine pathways involved in Local cryotherapy's local and systemic anti-inflammatory effects, which were mainly IL-6/IL-17A-driven and TNF-α independent in this model.