Alzheimer's disease brain-derived extracellular vesicles reveal altered synapse-related proteome and induce cognitive impairment in mice.

Victor Bodart-SantosLisandra S PinheiroAlmir J da Silva-JuniorRudimar L FrozaRosemary AhrensRafaella A GonçalvesMayara M AndradeYan ChenCarolina de Lima AlcantaraLea T GrinbergRenata E P LeiteSergio T FerreiraPaul E FraserFernanda G De Felice

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

Aβ was detected in EVs from post mortem AD brain tissue and APP/PS1 mice. Tau was enriched in EVs from post mortem AD, PSP and FTD brain tissue. AD-derived EVs and APP/PS1-EVs induce cognitive impairment in wild-type (WT) mice. AD- and FTD-derived EVs induce cognitive impairment in humanized Tau mice. Proteomics findings associate EVs with synapse dysregulation in tauopathies.

Keyphrases

cognitive impairment
wild type
high fat diet induced
white matter
resting state
mass spectrometry
type diabetes
metabolic syndrome
adipose tissue
cerebral ischemia
cognitive decline