Anxiety and depression mediate the association between chemotherapy-induced peripheral neuropathy and fatigue: Results from the population-based PROFILES registry.
Cynthia S BonhofLonneke V van de Poll-FransePauline A J VissersDareczka K WasowiczJohannes A WegdamDóra RévészGerard VreugdenhilFloortje MolsPublished in: Psycho-oncology (2019)
CRC survivors with high CIPN report more fatigue, especially those who are also anxious and/or depressed. More research is needed on the direction of the relationship between CIPN, psychological distress, and fatigue. For now, the treatment of fatigue should also focus on addressing psychological distress, as treating fatigue alone might not be sufficient.