Tumor-Stroma Crosstalk Enhances REG3A Expressions that Drive the Progression of Hepatocellular Carcinoma.

Yuri ChoMin Ji ParkKoeun KimJae-Young ParkJihye KimWonjin KimJung-Hwan Yoon

Published in: International journal of molecular sciences (2020)

REG3A/p42/44 pathway/PDGF-ββ signaling plays a significant role in hepatocarcinogenesis via tumor-stroma crosstalk. Targeting REG3A is a potential novel therapeutic target for the management of HCCs by inhibiting crosstalk between HCC cells and HSCs.

Keyphrases

induced apoptosis
signaling pathway
cell cycle arrest
cancer therapy
smooth muscle
cell death
endoplasmic reticulum stress