(Rose Bengal)/(Eosin Yellow)-Gold-Polypyrrole Hybrids: A Design for Dual Photo-Active Nano-System with Ultra-High Loading Capacity.

Abdullah I El-Kholy Doaa A Abdel Fadeel Maha Nasr Ibrahim Mohamed El-SherbinyMaha Fadel

Published in: Drug design, development and therapy (2021)

Gold-polypyrrole nanoparticles represent an effective delivery system to improve the photodynamic and photothermal properties of RB and EY. The in situ one-pot synthesis method provided a means to greatly increase the loading capacity of AuPpy NPs. While both hybrid nanocomposites exhibited greatly diminished dark cytotoxicity, RB-AuPpy NPs showed significantly enhanced photocytotoxicity compared to the free dyes. This pattern enables the safe use of both dyes in high concentrations with sustained action, reducing dose frequency and side effects.

Keyphrases

reduced graphene oxide
cancer therapy
molecularly imprinted
photodynamic therapy
drug delivery
high resolution
oxide nanoparticles
solid phase extraction