A novel unconventional T cell population enriched in Crohn's disease.
Elisa RosatiGabriela Rios MartiniMikhail V PogorelyyAnastasia A MinervinaFrauke DegenhardtMareike WendorffSoner SariGabriele MayrAntonella FazioChristel Marie DowdsCharlotte HauserFlorian TranWitigo von SchönfelsJulius PochhammerMaria A SalnikovaCharlot JaeckelJohannes Boy GiglaSanaz Sedghpour SabetMatthias HübenthalEsther SchiminskyStefan SchreiberPhilip C RosenstielAlexander ScheffoldPaul G ThomasWolfgang LiebBernd BokemeyerMaria WitteKonrad AdenAlexander HendricksClemens SchafmayerJan-Hendrick EgbertsIlgar Z MamedovPetra BacherAndre FrankePublished in: Gut (2022)
We identified and characterised a subpopulation of unconventional Crohn-associated invariant T (CAIT) cells. Multiple evidence suggests these cells to be part of the NKT type II population. The potential implications of this population for CD or a subset thereof remain to be elucidated, and the immunophenotype and antigen reactivity of CAIT cells need further investigations in future studies.