Characterization of urethral fibrosis in a rabbit model: Potential roles of Wnt-β catenin pathway and epithelial to mesenchymal transition.
Jesse W TaiHosong YuAbinav T ChilukuriRaag BhargavaRucha DeshpandeWei LiWeg M OngkekoValmik BhargavaMahadevan Raj RajasekaranPublished in: Neurourology and urodynamics (2020)
Our RNA sequencing and qPCR studies, in conjunction with our protein data, suggest that urethral mucosal fibrogenesis may be mediated by novel fibrogenic signaling pathways involving Wnt-β catenin, TGF-β, GIV/Girdin, and EMT which lead to increased collagen deposition. Therapeutic strategies targeting these pathways may be beneficial in attenuating fibrogenesis and stricture progression.
Keyphrases
- cell proliferation
- epithelial mesenchymal transition
- transforming growth factor
- signaling pathway
- stem cells
- urinary incontinence
- single cell
- pi k akt
- electronic health record
- cancer therapy
- big data
- binding protein
- amino acid
- wound healing
- small molecule
- artificial intelligence
- deep learning
- liver fibrosis
- induced apoptosis