Continuous evaluation of single-dose moxifloxacin concentrations in brain extracellular fluid, cerebrospinal fluid, and plasma: a novel porcine model.

Theis MariagerJ H TerkelsenM BueK Öbrink-HansenR NauC R BjarkamHenrik Nielsen Jacob Bodilsen

Published in: The Journal of antimicrobial chemotherapy (2024)

A single dose of weight-adjusted moxifloxacin administered intravenously did not achieve adequate target site concentrations within the uninflamed porcine brain ECF and CSF to reach the applied TB CNS target.

Keyphrases

cerebrospinal fluid
resting state
white matter
functional connectivity
cerebral ischemia
mycobacterium tuberculosis
body mass index
physical activity
weight loss
blood brain barrier