ISSLS PRIZE in basic science 2023: Lactate in lumbar discs-metabolic waste or energy biofuel? Insights from in vivo MRS and T2r analysis following exercise and nimodipine in healthy volunteers.

Pushpa Bhari Thippesamy Dr Shanmuganathan Rajasekaran Murugesh Eswaran Chandhan Murugan Raksha Algeri Karuppanan Sukumaran Sri Vijay Anand Rishi Mugesh Kanna Ajoy Prasad Shetty

Published in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2023)

MRS documented changes in lactate response to cellular demand which suggested a 'Lactate Symbiotic metabolic Pathway'. The differences in lactate response preceded changes in Proteoglycan/hydration and thus could be a dynamic radiological biomarker of early degeneration.

Keyphrases

public health
minimally invasive
high intensity
heavy metals
body composition