EGFR Oncogenic Mutations in NSCLC Impair Macrophage Phagocytosis and Mediate Innate Immune Evasion Through Up-Regulation of CD47.
Li-Yang HuWei-Tao ZhuangMao-Jian ChenJun LiaoDong-Fang WuYa-Xiong ZhangLan-Lan PangYi-Hua HuangTian-Qin MaoMeng-Juan YangPei-Jian PengJin-Xia LiangLiang ChenLin-Juan ZengLi ZhangWen-Feng FangPublished in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (2024)
EGFR-sensitizing mutation facilitates NSCLC's escape from innate immune attack through up-regulating CD47. Combination therapy incorporating CD47 blockade holds substantial promise for clinical translation in developing more effective therapeutic approaches against EGFR-mutant NSCLC.