LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons.

Chuyu ChenMeghan MasottiNathaniel ShepardVanessa PromesGiulia TombesiDaniel ArangoClaudia Manzoni Greggio ElisaSabine HilfikerYevgenia KozorovitskiyLoukia Parisiadou

Published in: bioRxiv : the preprint server for biology (2024)

Chen et al. demonstrate that haloperidol mediated changes in the striatal indirect pathway neurons and circuits are linked to Parkinson's disease associated LRRK2. Inhibiting LRRK2 kinase activity ameliorates the motoric side effects of haloperidol, suggesting a potential approach to alleviating the unwanted side effects of antipsychotics.

Keyphrases

parkinson disease
spinal cord
functional connectivity
signaling pathway
mouse model
tyrosine kinase
protein kinase