Hyperbaric oxygen preconditioning: a reliable option for neuroprotection.
Qin HuAnatol ManaenkoNathanael MateiZhenni GuoTing XuJiping TangArne P NeyrinckPublished in: Medical gas research (2016)
Brain injury is the leading cause of death and disability worldwide and clinically there is no effective therapy for neuroprotection. Hyperbaric oxygen preconditioning (HBO-PC) has been experimentally demonstrated to be neuroprotective in several models and has shown efficiency in patients undergoing on-pump coronary artery bypass graft (CABG) surgery. Compared with other preconditioning stimuli, HBO is benign and has clinically translational potential. In this review, we will summarize the results in experimental brain injury and clinical studies, elaborate the mechanisms of HBO-PC, and discuss regimes and opinions for future interventions in acute brain injury.
Keyphrases
- brain injury
- cerebral ischemia
- coronary artery bypass
- subarachnoid hemorrhage
- percutaneous coronary intervention
- patients undergoing
- liver failure
- multiple sclerosis
- physical activity
- current status
- acute coronary syndrome
- respiratory failure
- drug induced
- coronary artery disease
- intensive care unit
- human health
- atrial fibrillation