Involvement of Wnt7a in the role of M2c microglia in neural stem cell oligodendrogenesis.

Miriam MechaNatalia Yanguas-CasásAna FeliúLeyre MestreFrancisco Javier Carrillo-SalinasKristoffer RieckenDiego Gomez-NicolaCarmen Guaza

Published in: Journal of neuroinflammation (2020)

We define here the contribution of microglia to Wnt production depending on their activation state, with M1 microglia secreting the Wnt5a protein and M2c microglia secreting Wnt7a. Collectively, our data reveal the role of reparative microglia in NSC oligodendrogenesis with the involvement of Wnt7a.

Keyphrases

stem cells
inflammatory response
cell proliferation
neuropathic pain
spinal cord
gene expression
genome wide
single cell
big data
small molecule
cell therapy
deep learning