Oncogenic GNAS Uses PKA-Dependent and Independent Mechanisms to Induce Cell Proliferation in Human Pancreatic Ductal and Acinar Organoids.
Ridhdhi DesaiLing HuangRaul S GonzalezSenthil K MuthuswamyPublished in: Molecular cancer research : MCR (2024)
The study identifies an opportunity to discover a PKA-independent pathway downstream of oncogene GNAS for managing IPMN lesions and their progression to PDAC.