Gene variants for the WNT pathway are associated with severity in periodontal disease.

María-Victoria Ospina-Ch Mónica Acevedo-Godoy Sandra Janneth Perdomo Lara Lorena Chila-Moreno Gloria Inés Lafaurie Consuelo Romero-Sánchez

Published in: Clinical oral investigations (2024)

The presence of DKKrs1896367 and KREMENrs132274 variants in individuals without PD suggests that these single nucleotide polymorphisms could be protective factors for bone loss in PD. A very interesting finding is that the DKKrs1896368 variant was found in a high percentage of severe cases, suggesting that the presence of this variant may be related to the severe bone loss observed in PD.

Keyphrases

bone loss
copy number
early onset
stem cells
cell proliferation
genome wide
drug induced
transcription factor