Reliable quantification of 18F-GE-180 PET neuroinflammation studies using an individually scaled population-based input function or late tissue-to-blood ratio.

Ralph BuchertMeike DirksChristian SchützeFlorian WilkeMartin MamachAnn-Katrin WirriesHenning PflugradLinda HamannLaura B N LangerChristian WetzelMario LukacevicAndras PolyakMariella KesslerCarlotta PetruschFrank M BengelLilli GeworskiRainer RupprechtKarin WeissenbornTobias L RossGeorg Berding

Published in: European journal of nuclear medicine and molecular imaging (2020)

These results support the use of a population-based input function scaled with a single blood sample or the ROI-to-whole-blood ratio at a late time point for simplified quantitative analysis of 18F-GE-180 PET.

Keyphrases

computed tomography
positron emission tomography
pet ct
traumatic brain injury
lipopolysaccharide induced
high resolution
blood brain barrier
subarachnoid hemorrhage