β-Catenin Activation Reprograms Ammonia Metabolism to Promote Senescence Resistance in Hepatocellular Carcinoma.

Ye Wang Chunxiao Cheng Yanjun Lu Zhaowu Lian Qi Liu Yanchao Xu Yunzheng Li Huan Li Laizhu Zhang Xiang Jiang Binghua Li Decai Yu

Published in: Cancer research (2024)

Ammonia metabolism reprogramming mediated by aberrant activation of β-catenin induces resistance to senescence in HCC and can be targeted by inhibiting SLC4A11 as a potential therapy for β-catenin mutant liver cancer.

Keyphrases

epithelial mesenchymal transition
cell proliferation
dna damage
endothelial cells
signaling pathway
anaerobic digestion
stress induced
cancer therapy
human health
oxidative stress