Xanthones from securidaca inappendiculata antagonizes the anti-rheumatic effect of methotrexate by inhibiting reduced folate carrier 1.
Sa-Sa ZhangYi-Jin WuShu PanQi-Hai WangWen-Gang ChenZhong-Fang WangJin-Ying XuJian ZuoQin YinPublished in: Immunopharmacology and immunotoxicology (2022)
and MTX should be further optimized to achieve the goal of increasing efficiency and reducing toxicity.