Regulation of β-catenin by IGFBP2 and its cytoplasmic actions in glioma.

Published in: Journal of neuro-oncology (2020)

IGFBP2 induces TRIM33 which regulates the nuclear β-catenin protein. In addition, IGFBP2 stabilizes the cytoplasmic β-catenin which is involved in the regulation of Oct4 transcript and consequently induction of stemness of glioma cells.

Keyphrases

epithelial mesenchymal transition
cell proliferation
stem cells
signaling pathway
optical coherence tomography
diabetic retinopathy
small molecule
protein protein
rna seq
amino acid