Integrative Bioinformatics Analysis of The Cell Division Cycle and Ribosomal Pathways in The Rat Varicocele: Implications for Drug Discovery.

Ali Nasr-Esfahani Ali Valipour Motlagh Minoo Adib Kosar Pashaei Mohammad Hossein Nasr-Esfahani

Published in: Cell journal (2023)

The current investigation indicates that in varicocele the cell division cycle pathway is up-regulated while the ribosome pathway is down-regulated compared to controls. Based on these findings, dexamethasone could be considered a future candidate drug for the treatment of individuals with varicocele.

Keyphrases

drug discovery
single cell
bioinformatics analysis
cell therapy
transcription factor
bone marrow
combination therapy