A mathematical model relates intracellular TLR4 oscillations to sepsis progression.
Razvan Costin StanFrancisco G SorianoMaristela M de CamargoPublished in: BMC research notes (2018)
Using a set of three differential equations, we defined the TLR4 fluxes between relevant cell organelles. We obtained three different regions in the phase space: (1) a limit-cycle describing unstimulated physiological oscillations, (2) a fixed-point attractor resulting from moderate LPS stimulation that is resolved and (3) a double-attractor resulting from sustained LPS stimulation that leads to sepsis. We used this model to describe available hospital data of sepsis patients and we correctly characterize the clinical outcome of these patients.
Keyphrases
- end stage renal disease
- inflammatory response
- ejection fraction
- intensive care unit
- newly diagnosed
- acute kidney injury
- chronic kidney disease
- toll like receptor
- prognostic factors
- healthcare
- immune response
- stem cells
- septic shock
- single cell
- electronic health record
- patient reported outcomes
- high intensity
- mesenchymal stem cells
- machine learning
- cell therapy
- adverse drug
- acute care