Severe ileum bleeding following adjuvant capecitabine chemotherapy for locally advanced colon cancer: a case report and review of the literature.
You ZouShuang LiuJianhong WuZhen SunPublished in: World journal of surgical oncology (2021)
1. Gastrointestinal bleeding following capecitabine treatment in colorectal cancer patients might be life-threatening. 2. Terminal ileitis induced by capecitabine should always be considered in the differential diagnosis of severe gastrointestinal bleeding. 3. Awareness of the risk factors such as deficiency of dihydropyrimidine dehydrogenase, advanced age, or right colectomy may aid in reducing capecitabine-related morbidity. 4. When severe bleeding occurs, emergency surgery may achieve satisfactory outcomes if medical and endoscopic interventions are ineffective.
Keyphrases
- locally advanced
- phase ii study
- metastatic breast cancer
- metastatic colorectal cancer
- risk factors
- phase iii
- early onset
- rectal cancer
- healthcare
- atrial fibrillation
- squamous cell carcinoma
- minimally invasive
- emergency department
- early stage
- public health
- radiation therapy
- drug induced
- physical activity
- open label
- coronary artery bypass
- clinical trial
- ultrasound guided
- acute coronary syndrome
- weight loss
- glycemic control
- surgical site infection
- percutaneous coronary intervention