Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclitaxel in non-small cell lung cancer cells via Nrf2 inhibition.

Xiangcui ChenQipeng WuYueming ChenJiahao ZhangHuachao LiZhicheng YangYang YangYanchao DengLuyong ZhangBing Liu

Published in: British journal of pharmacology (2019)

Diosmetin selectively induced apoptosis and enhanced the efficacy of paclitaxel in NSCLC cells via ROS accumulation through disruption of the PI3K/Akt/GSK-3β/Nrf2 pathway. Therefore, diosmetin may be a promising candidate for adjuvant treatment of NSCLC.

Keyphrases

induced apoptosis
oxidative stress
signaling pathway
endoplasmic reticulum stress
small cell lung cancer
dna damage
advanced non small cell lung cancer
pi k akt
early stage
single cell
cell death
cell therapy
reactive oxygen species
cell cycle arrest
stem cells
brain metastases
replacement therapy
tyrosine kinase