Proteogenomic integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosis.
Savvina PrapiadouLuka ŽivkovićBarbara ThorandMarc J GeorgeSander W van der LaanRainer MalikChristian HerderWolfgang KoenigThor UelandOla KlevelandPal AukrustLars GullestadJuergen BernhagenGerard PasterkampAnnette PetersAroon D HingoraniJonathan RosandMartin DichgansChristopher D AndersonMarios K GeorgakisPublished in: medRxiv : the preprint server for health sciences (2023)
Integrating multiomics data, we found a proteomic signature of IL-6 signaling activation and mediators of its effects on cardiovascular disease. Our analyses suggest the interferon-γ-inducible chemokine CXCL10 to be a potentially causal mediator for atherosclerosis in three vascular compartments and as such could serve as a promising drug target for atheroprotection.