Alterations of pain pathways by experimental sleep disturbances in humans: Central pain-inhibitory, cyclooxygenase, and endocannabinoid pathways.

Monika Haack Larissa C EngertLuciana BesedovskyMichael R Goldstein Jaime K Devine Rammy DangKeeyon OliaVictoria MolinaSuzanne M BertischNavil SethnaNorah Simpson

Published in: Sleep (2023)

These findings suggest that central pain-inhibitory COX mechanisms through which sleep disturbances may contribute to chronic pain risk are sex specific, implicating the need for sex-differential therapeutic targets to effectively reduce chronic pain associated with sleep disturbances in both sexes.

Keyphrases

chronic pain
pain management
sleep quality
physical activity
nitric oxide