A Multimodality Myocardial Perfusion Phantom: Initial Quantitative Imaging Results.
Marije E KamphuisHenny KuipersH Remco LiefersJan van EsFrank F J SimonisMarcel J W GreuterCornelis H SlumpRiemer H J A SlartPublished in: Bioengineering (Basel, Switzerland) (2022)
This proof-of-concept study explores the multimodal application of a dedicated cardiac flow phantom for ground truth contrast measurements in dynamic myocardial perfusion imaging with CT, PET/CT, and MRI. A 3D-printed cardiac flow phantom and flow circuit mimics the shape of the left ventricular cavity (LVC) and three myocardial regions. The regions are filled with tissue-mimicking materials and the flow circuit regulates and measures contrast flow through LVC and myocardial regions. Normal tissue perfusion and perfusion deficits were simulated. Phantom measurements in PET/CT, CT, and MRI were evaluated with clinically used hardware and software. The reference arterial input flow was 4.0 L/min and myocardial flow 80 mL/min, corresponding to myocardial blood flow (MBF) of 1.6 mL/g/min. The phantom demonstrated successful completion of all processes involved in quantitative, multimodal myocardial perfusion imaging (MPI) applications. Contrast kinetics in time intensity curves were in line with expectations for a mimicked perfusion deficit (38 s vs. 32 s in normal tissue). Derived MBF in PET/CT and CT led to under- and overestimation of reference flow of 0.9 mL/g/min and 4.5 mL/g/min, respectively. Simulated perfusion deficit (0.8 mL/g/min) in CT resulted in MBF of 2.8 mL/g/min. We successfully performed initial, quantitative perfusion measurements with a dedicated phantom setup utilizing clinical hardware and software. These results showcase the multimodal phantom's potential.
Keyphrases
- contrast enhanced
- pet ct
- image quality
- dual energy
- left ventricular
- computed tomography
- magnetic resonance imaging
- magnetic resonance
- high resolution
- positron emission tomography
- blood flow
- diffusion weighted imaging
- heart failure
- traumatic brain injury
- mitral valve
- monte carlo
- left atrial
- pain management
- data analysis
- mass spectrometry
- fluorescence imaging