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Are Central and Systemic Inflammation associated with Fatigue in Cerebral Small Vessel Disease?

Amy A JollyRobin B BrownDaniel J TozerYoung T HongTim D FryerFranklin AigbirhioJohn O'brienHugh Stephen Markus
Published in: International journal of stroke : official journal of the International Stroke Society (2024)
In symptomatic SVD patients, neuroinflammation, assessed with microglial marker 11C-PK11195, was not associated with fatigue. We found some evidence for a role of systematic inflammation, evidenced by an association between fatigue severity and raised CRP, but further studies are required to understand this relationship and inform whether it could be therapeutically modified to reduce fatigue severity.
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