Are Central and Systemic Inflammation associated with Fatigue in Cerebral Small Vessel Disease?
Amy A JollyRobin B BrownDaniel J TozerYoung T HongTim D FryerFranklin AigbirhioJohn O'brienHugh Stephen MarkusPublished in: International journal of stroke : official journal of the International Stroke Society (2024)
In symptomatic SVD patients, neuroinflammation, assessed with microglial marker 11C-PK11195, was not associated with fatigue. We found some evidence for a role of systematic inflammation, evidenced by an association between fatigue severity and raised CRP, but further studies are required to understand this relationship and inform whether it could be therapeutically modified to reduce fatigue severity.
Keyphrases
- sleep quality
- end stage renal disease
- lipopolysaccharide induced
- ejection fraction
- chronic kidney disease
- newly diagnosed
- oxidative stress
- lps induced
- traumatic brain injury
- inflammatory response
- prognostic factors
- peritoneal dialysis
- depressive symptoms
- spinal cord injury
- neuropathic pain
- cognitive impairment
- blood brain barrier