A multi-site, international laboratory study to assess the performance of penicillin susceptibility testing of Staphylococcus aureus.
Andrew HendersonMatthew Pellan ChengKa Lip ChewGeoffrey W CoombsJoshua Saul DavisJennifer M GrantDan GregsonStefano G GiulieriBenjamin Peter HowdenTodd C LeeVi NguyenJocelyn M MoraSusan C MorpethJames O RobinsonSteven Y C TongSebastiaan J Van Halnull nullPublished in: The Journal of antimicrobial chemotherapy (2023)
The EUCAST method with a P1 disc resulted in a lower VME rate compared with the CLSI methods with a P10 disc. These results should be considered in the context that among collections of PSSA isolates, as determined by automated MIC testing, less than 10% harbour blaZ. Furthermore, the clinical relevance of phenotypically susceptible, but blaZ-positive S. aureus, remains unclear.