Mitochondrial DNA copy number associates with insulin sensitivity and aerobic capacity, and differs between sedentary, overweight middle-aged males with and without type 2 diabetes.
Dumitru Constantin-TeodosiuDespina ConstantinMaurice M PelsersLex B VerdijkImre Willemijn Kehinde KouwPaul L GreenhaffPublished in: International journal of obesity (2005) (2019)
Body composition and indices of muscle mitochondrial volume/function were similar between SC and ST2DM. However, mtDNAnum differed and was positively associated with ISI, HOMA-IR and V̇O2max across all groups. Collectively, the findings support the contention that habitual physical activity is a key component of T2DM development, possibly by influencing mtDNAnum.
Keyphrases
- body composition
- physical activity
- mitochondrial dna
- copy number
- middle aged
- glycemic control
- type diabetes
- resistance training
- bone mineral density
- genome wide
- oxidative stress
- skeletal muscle
- body mass index
- dna methylation
- weight loss
- high intensity
- sleep quality
- insulin resistance
- cardiovascular disease
- gene expression
- depressive symptoms
- metabolic syndrome
- adipose tissue