Sex specific molecular networks and key drivers of Alzheimer's disease.

Lei GuoJiqing CaoJianwei HouYonghe LiMin HuangLi ZhuLarry ZhangYeji LeeMariana Lemos DuarteXianxiao ZhouMinghui WangChia-Chen LiuYuka MartensMichael ChaoAlison GoateGuojun BuVahram HaroutunianDongming CaiBin Zhang

Published in: Molecular neurodegeneration (2023)

These findings provide insights into key mechanisms mediating sex differences in AD pathogenesis and will facilitate the development of sex- and APOE genotype-specific therapies for AD.

Keyphrases

cognitive decline
high fat diet
mild cognitive impairment
type diabetes
adipose tissue
single molecule
insulin resistance
skeletal muscle