Hepatic interleukin-1 receptor type 1 signalling regulates insulin sensitivity in the early phases of nonalcoholic fatty liver disease.

Nadine GehrkeLea J HofmannBeate K StraubFrank RühleAri WaismanPeter R GalleJörn Markus Schattenberg

Published in: Clinical and translational medicine (2022)

The current data highlights that hepatocyte IL-1R1 contributes to hepatic and extrahepatic insulin resistance. Future liver-directed therapies in NAFLD could have effects on insulin sensitivity when improving hepatic inflammation and IL-1R1 signalling.

Keyphrases

insulin resistance
oxidative stress
type diabetes
adipose tissue
metabolic syndrome
electronic health record
skeletal muscle
polycystic ovary syndrome
big data
current status
machine learning
artificial intelligence
liver fibrosis
high fat diet induced