Dendritic Cell Plasticity, Radiation, and Newton's Third Law.
Pawel KalinskiShipra GandhiKathleen M KokolusPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Regulatory T (Treg) cells protect damaged tissues but can undermine the effects of cancer treatments, including radiation (RTx). Intratumoral immuno-stimulatory dendritic cells (cDC1) respond to RTx with production of Treg-attracting MDC/CCL22, undermining RT effects. That effect can be reversed by EGFR-targeted IFNa, highlighting cDC1 plasticity and relevance as therapeutic targets.
Keyphrases
- dendritic cells
- induced apoptosis
- regulatory t cells
- immune response
- papillary thyroid
- small cell lung cancer
- cell cycle
- cell cycle arrest
- epidermal growth factor receptor
- gene expression
- transcription factor
- radiation induced
- cancer therapy
- squamous cell
- squamous cell carcinoma
- liver injury
- oxidative stress
- lymph node metastasis
- liver fibrosis
- cell proliferation
- childhood cancer
- drug induced