Integrating network pharmacology, UPLC-Q-TOF-MS and molecular docking to investigate the effect and mechanism of Chuanxiong Renshen decoction against Alzheimer's disease.
Zhuo Jun ShenYun Bo FuJin Ling HouLu Ning LinXiao Yan WangChang Yu LiYuan Xiao YangPublished in: Chinese medicine (2022)
CRD significantly alleviated injury in 3 × Tg-AD mice. The possible active ingredients are ferulic acid, rutin, ginsenoside Rg1 and panaxydol. The therapeutic effect of CRD on AD is achieved through the downregulation of CASP3 and EGFR. The neuroprotective effect of CRD on AD may occur through regulation of the MAPK signaling pathway.
Keyphrases
- molecular docking
- signaling pathway
- pi k akt
- molecular dynamics simulations
- small cell lung cancer
- induced apoptosis
- epithelial mesenchymal transition
- epidermal growth factor receptor
- cell proliferation
- tyrosine kinase
- oxidative stress
- high fat diet induced
- mass spectrometry
- skeletal muscle
- adipose tissue
- insulin resistance
- liquid chromatography
- network analysis