The role of SF3B1 and NOTCH1 in the pathogenesis of leukemia.
Shiva AbolhasaniSeyyed Sina HejazianVahid KarpishehAtefeh KhodakaramiHamed MohammadiJamshid Gholizadeh NavashenaqMohammad Hojjat-FarsangiFarhad Jadidi-NiaraghPublished in: IUBMB life (2022)
The discovery of new genes/pathways improves our knowledge of cancer pathogenesis and presents novel potential therapeutic options. For instance, splicing factor 3b subunit 1 (SF3B1) and NOTCH1 genetic alterations have been identified at a high frequency in hematological malignancies, such as leukemia, and may be related to the prognosis of involved patients because they change the nature of malignancies in different ways like mediating therapeutic resistance; therefore, studying these gene/pathways is essential. This review aims to discuss SF3B1 and NOTCH1 roles in the pathogenesis of various types of leukemia and the therapeutic potential of targeting these genes or their mutations to provide a foundation for leukemia treatment.
Keyphrases
- high frequency
- acute myeloid leukemia
- genome wide
- bone marrow
- end stage renal disease
- cell proliferation
- transcranial magnetic stimulation
- genome wide identification
- ejection fraction
- chronic kidney disease
- newly diagnosed
- small molecule
- papillary thyroid
- copy number
- prognostic factors
- peritoneal dialysis
- drug delivery
- gene expression
- genome wide analysis
- high throughput
- patient reported outcomes
- young adults
- protein kinase