STAT2/Caspase3 in the diagnosis and treatment of psoriasis.

Zhibing FuYi HeLihua GaoXiaoliang TongLu ZhouJinrong Zeng

Published in: European journal of clinical investigation (2023)

In summary, STAT2 overexpression contributes to psoriasis progression by regulating Capase3 phosphorylation to induce excessive apoptosis of keratinocytes. Meanwhile, STAT2 and Capase3 were identified as promising biomarkers for the diagnosis and treatment of psoriasis and could be used for individualized treatments.

Keyphrases

cell proliferation
cell death
atopic dermatitis
oxidative stress
endoplasmic reticulum stress
cell cycle arrest
induced apoptosis
body mass index
protein kinase
pi k akt