Silver and Copper Nanoparticles Induce Oxidative Stress in Bacteria and Mammalian Cells.
Thelma AmehMatthew GibbDinny StevensSahar H PradhanW Evan BraswellChristie M SayesPublished in: Nanomaterials (Basel, Switzerland) (2022)
Silver and copper nanoparticles (AgNPs and CuNPs) coated with stabilizing moieties induce oxidative stress in both bacteria and mammalian cells. Effective antibacterial agents that can overcome existing mechanisms of antibacterial resistance will greatly improve biomedical interventions. In this study, we analyzed the effect of nanoparticle-induced stress. Escherichia coli and normal human bronchial epithelial (BEAS-2B) cells were selected for this study. The nanoparticle constructs tested showed low toxicity to mammalian cells except for the polyvinylpyrrolidone-surface-stabilized copper nanoparticles. In fact, both types of copper nanoparticles used in this study induced higher levels of reactive oxygen species than the surface-stabilized silver nanoparticles. In contrast to mammalian cells, the surface-stabilized silver and copper nanoparticles showed varying levels of toxicity to bacteria cells. These data are expected to aid in bridging the knowledge gap in differential toxicities of silver and copper nanoparticles against bacteria and mammalian cells and will also improve infection interventions.
Keyphrases
- silver nanoparticles
- oxidative stress
- escherichia coli
- gold nanoparticles
- oxide nanoparticles
- diabetic rats
- induced apoptosis
- reactive oxygen species
- healthcare
- magnetic resonance
- dna damage
- physical activity
- machine learning
- pseudomonas aeruginosa
- cystic fibrosis
- drug induced
- computed tomography
- cell death
- magnetic resonance imaging
- biofilm formation
- heat shock
- cell proliferation
- heat stress
- cell cycle arrest
- electronic health record
- candida albicans
- wound healing
- iron oxide