Intestinal Epithelial Deletion of Sphk1 Prevents Colitis-Associated Cancer Development by Inhibition of Epithelial STAT3 Activation.

Seung Bin ParkByung-Il ChoiBeom Jae LeeNam Joo KimYoon A JeongMoon Kyung JooHyo Jung KimJong-Jae ParkJae Seon KimYoon-Seok NohHyun Joo Lee

Published in: Digestive diseases and sciences (2019)

Epithelial conditional deletion of Sphk1 inhibits CAC in ApcMin/+-DSS models in mice by inhibiting STAT3 activation and its target signaling pathways.

Keyphrases

signaling pathway
cell proliferation
type diabetes
epithelial mesenchymal transition
high fat diet induced
pi k akt
squamous cell
squamous cell carcinoma
metabolic syndrome
oxidative stress
young adults
insulin resistance
endoplasmic reticulum stress
induced apoptosis
childhood cancer