A Real-world Toxicity Atlas Shows that Adverse Events of Combination Therapies Commonly Result in Additive Interactions.

Asli Küçükosmanoglu Silvia Scoarta Megan Houweling Nicoleta Spinu Thomas Wijnands Niek Geerdink Carolien Meskers Georgi K Kanev Bert Kiewiet Mathilde C M Kouwenhoven David P Noske Tom Wurdinger Marianne G Pouwer Mark Wolff Bart A Westerman

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Our study provides a framework for analyzing adverse events and suggests that adverse drug interactions commonly result in additive effects with a high level of overlap of adverse event patterns. These real-world insights may advance the implementation of new combination therapies in clinical practice.

Keyphrases

adverse drug
clinical practice
electronic health record
primary care
healthcare
emergency department
oxidative stress
single cell
quality improvement