AIE-active iridium(III) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy.

Shengnan LiuJiahong HanYulei ChangWeijin WangRunlin WangZiwei WangGuangzhe LiDongxia Zhu Martin R Bryce

Published in: Chemical communications (Cambridge, England) (2022)

The integration of an aggregation induced emission (AIE)-active Ir(III) complex and upconversion nanoparticles (UCNPs) has achieved a NIR-irradiated photosensitizer (PS), UCNPs@Ir-2-N. This PS has satisfactory biocompatibility, excellent phototoxicity, good accumulation in cells and high 1 O 2 generation ability, thereby effectively killing 4T1 mouse cancer cells in vitro . This work has potential for future photodynamic therapy (PDT) applications.

Keyphrases

photodynamic therapy
fluorescence imaging
fluorescent probe
induced apoptosis
living cells
cell cycle arrest
current status
endoplasmic reticulum stress
walled carbon nanotubes
risk assessment
cell death
climate change