AIE-active iridium(III) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy.
Shengnan LiuJiahong HanYulei ChangWeijin WangRunlin WangZiwei WangGuangzhe LiDongxia ZhuMartin R BrycePublished in: Chemical communications (Cambridge, England) (2022)
The integration of an aggregation induced emission (AIE)-active Ir(III) complex and upconversion nanoparticles (UCNPs) has achieved a NIR-irradiated photosensitizer (PS), UCNPs@Ir-2-N. This PS has satisfactory biocompatibility, excellent phototoxicity, good accumulation in cells and high 1 O 2 generation ability, thereby effectively killing 4T1 mouse cancer cells in vitro . This work has potential for future photodynamic therapy (PDT) applications.