Doravirine responses to HIV-1 viruses bearing mutations to NRTIs and NNRTIs under in vitro selective drug pressure.

Bluma G BrennerMaureen OliveiraRuxandra-Ilinca IbanescuJean-Pierre RoutyRéjean Thomas

Published in: The Journal of antimicrobial chemotherapy (2023)

Doravirine showed favourable resistance profiles against viruses harbouring NRTI and NNRTI RAMs. The high barrier to resistance to doravirine coupled with the long intracellular half-life of islatravir may provide the opportunity for long-acting treatment options.

Keyphrases

antiretroviral therapy
hiv positive
human immunodeficiency virus
hiv infected
hepatitis c virus
hiv aids
hiv testing
reactive oxygen species
drug induced
south africa