Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract.

Huanwen WuZicheng YuYueping LiuLei GuoLianghong TengLingchuan GuoLi Liang Jing WangJie GaoRuiyu LiLing YangXiu NieDan SuZhiyong Liang

Published in: Cancer communications (London, England) (2022)

GI-NECs harbor distinct genomic landscapes and demonstrate significant genetic heterogeneity across different anatomic locations. Moreover, potentially actionable alterations and prognostic factors were revealed for GI-NECs.

Keyphrases

prognostic factors
copy number
single cell
genome wide
high grade
dna methylation
gene expression