BNT162b2 vaccination enhances interferon-JAK-STAT-regulated antiviral programs in COVID-19 patients infected with the SARS-CoV-2 Beta variant.

Ludwig KnablHye Kyung LeeManuel WieserAnna MurAugust ZaberniggLudwig KnablSimon RauchMatthias BockJana SchumacherNorbert KaiserPriscilla A Furth Lothar Hennighausen

Published in: Communications medicine (2022)

Our study demonstrates that RNA-seq can be used to monitor molecular immune responses elicited by the BNT162b2 vaccine, both in naïve individuals and in COVID-19 patients, and it provides a biomarker-based approach to systems vaccinology.

Keyphrases

sars cov
rna seq
single cell
immune response
respiratory syndrome coronavirus
dendritic cells
public health
transcription factor
toll like receptor
single molecule
inflammatory response