Association of CSF orexin-A levels and nocturnal sleep stability in patients with hypersomnolence.
Lucie BarateauRégis LopezSofiene CheniniAnna-Laura RassuSabine ScholzManuela LotierzoJean-Paul CristolIsabelle JaussentYves DauvilliersPublished in: Neurology (2020)
This study shows an association between ORX levels and nocturnal sleep stabilization in patients with hypersomnolence. Sleep and wake bouts are reliable markers of nighttime sleep stability that correlate with CSF ORX levels in a dose-dependent manner.