Circulating fibrocytes traffic to the lung in murine acute lung injury and predict outcomes in human acute respiratory distress syndrome: a pilot study.
Christine M LinAbdullah AlrbiaanJohn OdackalZhimin ZhangYogesh ScindiaSun-Sang J SungMarie D BurdickBorna MehradPublished in: Molecular medicine (Cambridge, Mass.) (2020)
Circulating fibrocytes increase in a murine model of acute lung injury and elevation in the number of these cells above a certain threshold is correlated with mortality in human ARDS. Therefore, these cells may provide a useful and easily measured biomarker to predict outcomes in these patients.
Keyphrases
- acute respiratory distress syndrome
- induced apoptosis
- endothelial cells
- extracorporeal membrane oxygenation
- mechanical ventilation
- cell cycle arrest
- lipopolysaccharide induced
- lps induced
- ejection fraction
- induced pluripotent stem cells
- air pollution
- type diabetes
- signaling pathway
- cell death
- risk factors
- inflammatory response
- cardiovascular disease
- oxidative stress
- skeletal muscle
- intensive care unit
- patient reported outcomes
- chronic kidney disease
- cell proliferation