Dll1-Mediated Notch Signaling Drives Tumor Cell Cross-talk with Cancer-Associated Fibroblasts to Promote Radioresistance in Breast Cancer.

Ajeya NandiRahul DebnathAnupma NayakTsun Ki Jerrick ToGatha ThackerMegan ReillySanjeev GumberIlias V Karagounis Ning Li Christopher J LengnerMalay HaldarAlana L WelmAndres M BlancoChristoforos Thomas Rumela Chakrabarti

Published in: Cancer research (2022)

Dll1+ breast cancer cells activate Notch signaling in cancer-associated fibroblasts that increases Wnt ligand secretion and leads to β-catenin-driven radioresistance and metastasis, opening new therapeutic avenues for breast cancer.

Keyphrases

breast cancer cells
cell proliferation
extracellular matrix
dna damage response
stem cells
single cell
cell therapy
epithelial mesenchymal transition
cancer stem cells
oxidative stress
mesenchymal stem cells
young adults
breast cancer risk
childhood cancer