Polygenic Effect on Tau Pathology Progression in Alzheimer's Disease.

Anna RubinskiSimon FrerichRainer MalikNicolai Franzmeier Alfredo RamirezMartin DichgansMichael Ewersnull null

Published in: Annals of neurology (2022)

Our results demonstrate that the PGS predicts faster tau progression and thus cognitive decline, showing utility to enhance statistical power in clinical trials. ANN NEUROL 2023.

Keyphrases

cognitive decline
mild cognitive impairment
clinical trial
cerebrospinal fluid
phase ii
study protocol
double blind