Characterization of Early Inflammatory Events Leading to Provoked Vulvodynia Development in Rats.

Yaseen Awad-IgbariaShilo DadonAlon ShamirAlejandro LivoffMark ShlapoberskyJacob Bornstein Palzur Eilam

Published in: Journal of inflammation research (2022)

The present findings suggest that vulvar hypersensitivity is mediated by MCs accumulation, nerve growth, and neuromodulation of TRPV1 and TRPA1. Hence, KF treatment during the critical period of inflammation contributes to preventing chronic vulvar pain development.

Keyphrases

oxidative stress
neuropathic pain
chronic pain
sentinel lymph node
pain management
drug induced
radiation therapy
neoadjuvant chemotherapy
spinal cord
squamous cell