GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase.
Roger J LiangSamuel TaylorNavid NahiyaanJunho SongCharles J MurphyEzequiel DantasShuyuan ChengTing-Wei HsuShakti RamsamoojRahul GroverSeo-Kyoung HwangBryan NgoLewis C CantleyKyu Y RheeMarcus DaSilva GoncalvesPublished in: Cancer & metabolism (2021)
We show that GLUT5 is a robust and generalizable driver of fructose-dependent cell proliferation. This indicates that fructose uptake is the limiting factor for fructose-mediated cell proliferation. We further demonstrate that cellular proliferation with fructose is independent of KHK.