Effects of red blood cells with reduced deformability on cerebral blood flow and vascular water transport: measurements in rats using time-resolved pulsed arterial spin labelling at 9.4 T.

Adnan BibicTea SordiaErik HenningssonLinda KnutssonFreddy StåhlbergRonnie Wirestam

Published in: European radiology experimental (2021)

Haemodynamic changes caused by injection of damaged RBCs were observed by ASL-based CBF and CTT measurements. Damaged RBCs can be used as a tool for test and validation of perfusion imaging modalities. CTT model fitting was challenging to stabilise at experimental signal-to-noise ratio levels, and the number of free parameters was minimised.

Keyphrases

cerebral blood flow
red blood cell
high resolution
room temperature
air pollution
single molecule
density functional theory
contrast enhanced
ultrasound guided
magnetic resonance
molecular dynamics
fluorescence imaging